As a composer-in-residence, Serre-Milan visited many experimental music production and research organizations around the world, including Ircam, Ircam, Ircam, Ircam, Ircam, Ircam, and Ircam. Serre-Milan's works were commissioned by Ircam and several prominent French ensembles, such as the Orchestre Philharmonique De Radio France, Ensemble Orchestral De Paris, and Orchestre De Lyon. In 2006, his …Pour quelques âmes volées for female voice and orchestra was selected for the UNESCO International Rostrum of Composers.

Since 2002, André Serre-Milan has been working in duo with a composer Yé Lassina Coulibaly. He started developing an innovative pedagogical approach to the electro-acoustic composition with Carl Faia at Ircam in 2005; the research culminated in the annual multimedia spectacle Sonoscopie. Serre-Milan also collaborated with Art Zoyd and numerous other musicians, writers, choreographers, stage directors and visual artists.